Pustular psoriasis

About pustular psoriasis (localized or generalized form)

In the case of pustular psoriasis, it should be noted that these bubbles are aseptic, i.e. non-infected. However, these lesions are often highly inflammatory. The profile of patients with pustular psoriasis varies, but a personal and/or family history of plaque psoriasis is fairly common. This type of psoriasis is divided into two main categories:

• A localized form, mainly occurring on the palms of the hands and soles of the feet (palmoplantar pustular psoriasis). This form of psoriasis can lead to the onset of motor difficulties (e.g. with walking or grasping objects) and often major social problems (fear of other people staring, loneliness and withdrawal);
• A generalized form, also known as Von Zumbusch pustular psoriasis, which constitutes a medical emergency and can result in death. Generalized pustular psoriasis is associated with various extracutaneous symptoms: fever, fatigue, deterioration of general health, electrolyte disorders, multi-organ and especially joint and pulmonary involvement, with a risk of respiratory problems. Generalized pustular psoriasis can develop in the form of flare-ups as with plaque psoriasis.

How is pustular psoriasis treated?

Treatment for pustular psoriasis is the same as for plaque psoriasis, with particular emphasis on treatments taken orally or by injection. In life-threatening cases of generalized pustular psoriasis, hospitalization is often necessary to monitor the patient's vital signs while administering treatment.