Medicines to manage psoriasis

When local treatments (creams, lotions, ointments, etc.) are not sufficient, dermatologists may often suggest trying a medicinal treatment in tablet form, especially when psoriasis is widespread.

Different medicines

Oral treatments for psoriasis are usually formulated using one of the following four molecules:

Methotrexate

This drug limits cell proliferation. It has been used for many years to treat psoriasis, and it is available in tablet or injection form. Caution! This treatment is unusual in that it is taken once a week and not once a day. It can be taken alone or in combination with biotherapy. Adverse reactions are possible, such as fatigue, digestive disorders, mouth ulcers, hair loss, etc. More serious effects such as liver damage can be prevented with regular check-ups.

Cyclosporine

This drug is an immunosuppressant, regularly used in organ transplants. Cyclosporine cannot be administered long-term due to certain adverse effects, including severe renal toxicity. On the other hand, a one- or two-year treatment can help patients to get over a critical stage of inflammation and limit psoriasis activity.

Acitretin

This molecule acts by regulating keratinocyte activity. Its use is highly restricted, particularly in young women of childbearing age, because of its teratogenic nature. Use of effective contraception and close monitoring are necessary. The most frequently reported adverse reactions involve The skin/mucosae: dry skin and lips, fragile nails and hair, etc. Daily use of hydrating and repairing skin care products is recommended.

Apremilast

This new drug targets inflammatory processes. It is well-tolerated, although some digestive problems have been reported. Patients can also develop mood disorders, which although rare can be potentially serious.

Research is ongoing to develop and commercialize new drugs for the treatment of psoriasis.